Transplanting the Islets of Langerhans for a Diabetes Cure
86Islets of Langerhans
In a public elementary school, my classmates and I were incorrectly taught that the "Isles of Langerhans" were 2 sizable glands that sit on the underside of the pancreas. During the same year, we were taught (from textbooks with the matching pictures) that ALL men have one fewer rib on their left sides, because Eve came from the side of Adam. Also during the same year, we were taught that the kiwi bird was extinct. None of these things were true. Since so many people are gadding about in costumes this week, I keep imagining a skeleton holding a stuffed kiwi and examining fictitious organs in a jar from a particular Twilight Zone episode.
The islets are not two glands but several clusters of cells throughout the pancreas that account for about 1-2% of its makeup. I wonder how it was felt that the islets were glands when no glands appear on the dorsal side of the pancreas; and all the rest of it we were taught? This all speaks to the lack of science education for teachers at the elementary grades level.
Futurist writer Harlan Ellison® has a web page dedicated to him called Islets of Langerhans, perhaps to point out the ludicrous fallacies we're taught, but certainly to point out the sugar-coating the media placed on news items they have wished to bury in the 1970s unto today (one of Ellison's missions being top remove that coating).
The cell clusters in the pancreas produce insulin. A pancreas implant, usually paired with a kidney transplant in a diabetic human beyond all other hope, can cure Type I and Type II Diabetes -- In the film Repo Men, computerized artificial pancreases did the trick. Further, transplanting a large number of Islets of Langerhans from a donor pancrease can produce positive results and clinical trials are gathering additional research in order to perfect these techniques.
Islets of Langerhans
Pancreatic Cells
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIDDK reports that the islets of Langerhans may be successfully transplanted. In clinical trials, a massive number of islets are extracted from an organ donor's pancreas and implanted into a patient suffering Type I Diabetes.
After a certain time period, the beta cells within the islets begin to produce insulin. Research has been collected regarding this set of procedures since 2000 or earlier, but the procedures may have been conceptualized in the 18th or 19th Centuries. Research is pointing to the fact that at least 1,000,000 islets are required to take the place of daily injections of insulin, and examining the success of artificial membranes to hold the islets in a sort of bioengineered pancreas, and the efficacy of transplanting pig islets.
See the links below for references and entire articles.
- What's Hot: Islet Cell Transplantation
- Alcohol may slow and prevent Islet transplantation results
Continuous, but Not Occasional, Oral Ethanol Intake Reduces the Success of Intraportal Transplanted Islets of Langerhans: An Experimental Study X. Liua, S. Matsumotob, H. Noguchib, Y. Yonekawac, Y. Iwanagad, T. Okitsud, H. Nagatae, S. Miyakawae, C - Bioartificial Pancreas can hold the Islets
Bioartificial pancreas: Microencapsulation and conformal coating of islet of Langerhans. Yuji Teramuraa and Hiroo Iwatab. June 2010. - Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study -- Va
Transplant: Pig to Human - National Diabetes Information Clearinghouse - NIDDK
Provides educational materials to increase knowledge and understanding about diabetes among patients, health care professionals, and the general public.
Impact on Future Research
The above articles and additional research pieces suggest that even after a successful transplant of islets, the pancreas can be affected adversely by unwise health choices, such as ingesting too much alcohol, smoking, and the usual obesity and lack of exercize. It would be possible to have Type I Diabetes, be cured by an Islets of Langerhans implantation, and then to develop Type II Diabetes. As the film Repo Men tells us, transplatation is not enough, but is best a part of a healthy life in which wiser choices are made.
- Horrors Of the Repossessed - Transplant Tales
Years ago, a neighbor woke up in the morning, prepared to go to work and, stepping outside her front door, found that her car had vanished. She reported it stolen, but learned later that day that her vehicle...
Islets of Langerhans
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Hello, Patty, thank you for a very timely hub because I am having a liver operation removing a non-cancerous fibroyd from the bottom of my liver. Would that effect my pancrass? I hope I don't end up with diabetes. Maybe you would be so kind and shed some more light on all this.
This is a great article. I am diabetic, type 2 and it is basically controlled by diet. I do take pills to help control my diabetes. My mom has diabetes also and she is always crashing, two weeks ago her sugar level was 32. We found her on the floor of her apartment unresponsive, needless to say we were very upset because we didn't even know how long she had been this way. It was the grace of God that kept her. This information really hits close to home for me, any articles that you write on diabetes would be much appreciated. Thanks for this informative hub.
Wow that is great information. It would be a great break through for Diabetes sufferers. Thanks for the great hub!
My family are part of the Bart Oxford study for type 1 diabetes - a world leader in research. My son was one of the youngest in Britain to have developed the condition.
Actually, there are people who are walking around (Washington) with this transplant (source: Balance, Diabetes UK 2001).
They are creating these cells from stem cells - unfortunately, the USA are anti in this field of research (creating cells from embryos), but the UK are world leaders in this with great success.
This is one of my specialist areas and it might benefit your readers to read my course on this very subject. I taught this to A-Level students for my further ed qualification.
http://hubpages.com/hub/Diabetes-Awareness-in-Chil
It always amazes me that these tiny cells, of around a dozen, can create such devistating results when they die. We have very nearly lost our son on numerous occasions - if only we could have this transplant, without the anti rejection drugs (the effects of which can be just as bad as with the condition - high risk of cancer etc).
Thank you soooo much for helping to raise more awareness in this - unless you have lived with someone with this condition, no one can conceive the cruelty that this disease can create.
Thanks for sharing this well researched hub.
My partner has type 2 diabetes and any new reading material is welcome. I am giving this a useful and bookmarking so that I can get to it easily for reference.
Take care Patty.
The Thyroid plays a major role in diabetes
Hi Patty,
Great article cleverly written on an important, yet seldom covered topic. Love the graphics and the opening paragraph. It's amazing how much of what we learned in school was incorrect. I voted you up for originality, content usefulness and for bringing attention to a relatively new medical achievement!
The thyroid plays a major part in your entire make-up. I thought I was going crazy and it took forever to get a diasnosis. I ended up having Hypothyroidism. Not fun and very dangerous.
There is so much involved in our good health; genetic make-up, our choices (a big one) and as Seakay said, knowledge of the thyroid which affects every system of the body, including the brain. Our choices, as you stated, have a lot to do with it (even with the involvement of genetics). Voted and rated.
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travel_man1971 Level 6 Commenter 19 months ago
This is what I've found out:
In an experimental procedure called islet transplantation, islets are taken from the pancreas of a deceased organ donor. The islets are purified, processed, and transferred into another person. Once implanted, the beta cells in these islets begin to make and release insulin. Researchers hope that islet transplantation will help people with type 1 diabetes live without daily injections of insulin.
Hope it helps, Patty. :D