Transplanting the Islets of Langerhans for a Diabetes Cure

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By Patty Inglish, MS

Islets of Langerhans

In a public elementary school, my classmates and I were incorrectly taught that the "Isles of Langerhans" were 2 sizable glands that sit on the underside of the pancreas. During the same year, we were taught (from textbooks with the matching pictures) that ALL men have one fewer rib on their left sides, because Eve came from the side of Adam. Also during the same year, we were taught that the kiwi bird was extinct. None of these things were true. Since so many people are gadding about in costumes this week, I keep imagining a skeleton holding a stuffed kiwi and examining fictitious organs in a jar from a particular Twilight Zone episode.

The islets are not two glands but several clusters of cells throughout the pancreas that account for about 1-2% of its makeup. I wonder how it was felt that the islets were glands when no glands appear on the dorsal side of the pancreas; and all the rest of it we were taught? This all speaks to the lack of science education for teachers at the elementary grades level.

Futurist writer Harlan Ellison® has a web page dedicated to him called Islets of Langerhans, perhaps to point out the ludicrous fallacies we're taught, but certainly to point out the sugar-coating the media placed on news items they have wished to bury in the 1970s unto today (one of Ellison's missions being top remove that coating).

The cell clusters in the pancreas produce insulin. A pancreas implant, usually paired with a kidney transplant in a diabetic human beyond all other hope, can cure Type I and Type II Diabetes -- In the film Repo Men, computerized artificial pancreases did the trick. Further, transplanting a large number of Islets of Langerhans from a donor pancrease can produce positive results and clinical trials are gathering additional research in order to perfect these techniques.

Pancreatic Cells

Lithograph produced from Gray's Anatomy.
See all 3 photos
Lithograph produced from Gray's Anatomy.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIDDK reports that the islets of Langerhans may be successfully transplanted. In clinical trials, a massive number of islets are extracted from an organ donor's pancreas and implanted into a patient suffering Type I Diabetes.

After a certain time period, the beta cells within the islets begin to produce insulin. Research has been collected regarding this set of procedures since 2000 or earlier, but the procedures may have been conceptualized in the 18th or 19th Centuries. Research is pointing to the fact that at least 1,000,000 islets are required to take the place of daily injections of insulin, and examining the success of artificial membranes to hold the islets in a sort of bioengineered pancreas, and the efficacy of transplanting pig islets.

See the links below for references and entire articles.

Human Digestive System highlights.
Human Digestive System highlights.

Impact on Future Research

The above articles and additional research pieces suggest that even after a successful transplant of islets, the pancreas can be affected adversely by unwise health choices, such as ingesting too much alcohol, smoking, and the usual obesity and lack of exercize. It would be possible to have Type I Diabetes, be cured by an Islets of Langerhans implantation, and then to develop Type II Diabetes. As the film Repo Men tells us, transplatation is not enough, but is best a part of a healthy life in which wiser choices are made.   

Comments

travel_man1971 profile image

travel_man1971 Level 6 Commenter 19 months ago

This is what I've found out:

In an experimental procedure called islet transplantation, islets are taken from the pancreas of a deceased organ donor. The islets are purified, processed, and transferred into another person. Once implanted, the beta cells in these islets begin to make and release insulin. Researchers hope that islet transplantation will help people with type 1 diabetes live without daily injections of insulin.

Hope it helps, Patty. :D

Hello, hello, profile image

Hello, hello, 19 months ago

Hello, Patty, thank you for a very timely hub because I am having a liver operation removing a non-cancerous fibroyd from the bottom of my liver. Would that effect my pancrass? I hope I don't end up with diabetes. Maybe you would be so kind and shed some more light on all this.

ladyt11 19 months ago

This is a great article. I am diabetic, type 2 and it is basically controlled by diet. I do take pills to help control my diabetes. My mom has diabetes also and she is always crashing, two weeks ago her sugar level was 32. We found her on the floor of her apartment unresponsive, needless to say we were very upset because we didn't even know how long she had been this way. It was the grace of God that kept her. This information really hits close to home for me, any articles that you write on diabetes would be much appreciated. Thanks for this informative hub.

Patty Inglish, MS profile image

Patty Inglish, MS Hub Author 19 months ago

Hello hello - Best wishes for coming through the surgery without complications. At first glance, I don't think your pancreas should be affected by the surgery, but ask your surgeon what he thinks for added assurance, because he is your own personal expert. I think that your medical professionals will be following up with your for chjanges in blood chemistry aftre surgrey; ask them about blood sugar/glucose levels. It is smart of you to think about this and ask the question about liver-pancreatic involvement.

ladyt11 - Within 2 years, 2 friends in different states sxperienced this as well, terrifying their wives. They were helped by the EMTs that arrived, though. Another acquaintance suffered a drop in blood sugar and electrolytes all at once and suffered delusions that kept him hospitalized a frew days. He was miserable, but was helped with the proper IV soultions. Diabetes is really no lighteight matter. Thanks for posting.

Now, if enough people can afford the injection of islets with insurance coverage, this might be a big help.

bayareagreatthing profile image

bayareagreatthing Level 2 Commenter 19 months ago

Wow that is great information. It would be a great break through for Diabetes sufferers. Thanks for the great hub!

shazwellyn profile image

shazwellyn Level 4 Commenter 19 months ago

My family are part of the Bart Oxford study for type 1 diabetes - a world leader in research. My son was one of the youngest in Britain to have developed the condition.

Actually, there are people who are walking around (Washington) with this transplant (source: Balance, Diabetes UK 2001).

They are creating these cells from stem cells - unfortunately, the USA are anti in this field of research (creating cells from embryos), but the UK are world leaders in this with great success.

This is one of my specialist areas and it might benefit your readers to read my course on this very subject. I taught this to A-Level students for my further ed qualification.

http://hubpages.com/hub/Diabetes-Awareness-in-Chil

It always amazes me that these tiny cells, of around a dozen, can create such devistating results when they die. We have very nearly lost our son on numerous occasions - if only we could have this transplant, without the anti rejection drugs (the effects of which can be just as bad as with the condition - high risk of cancer etc).

Thank you soooo much for helping to raise more awareness in this - unless you have lived with someone with this condition, no one can conceive the cruelty that this disease can create.

Eiddwen profile image

Eiddwen 19 months ago

Thanks for sharing this well researched hub.

My partner has type 2 diabetes and any new reading material is welcome. I am giving this a useful and bookmarking so that I can get to it easily for reference.

Take care Patty.

Patty Inglish, MS profile image

Patty Inglish, MS Hub Author 19 months ago

shzwellyn - Good health to your son and your family! The stem-cell work in this area is new to me. Your link is a goo done for us to have. I'll read it and material about the study, so thanks vrey much for sharing this information.

Eiddwen - I do hope it's helpful. Thanks for posting.

someonewhoknows profile image

someonewhoknows 19 months ago

The Thyroid plays a major role in diabetes

http://search.netzero.net/search?action=search&sou

Happyboomernurse profile image

Happyboomernurse Level 8 Commenter 19 months ago

Hi Patty,

Great article cleverly written on an important, yet seldom covered topic. Love the graphics and the opening paragraph. It's amazing how much of what we learned in school was incorrect. I voted you up for originality, content usefulness and for bringing attention to a relatively new medical achievement!

Seakay profile image

Seakay 19 months ago

The thyroid plays a major part in your entire make-up. I thought I was going crazy and it took forever to get a diasnosis. I ended up having Hypothyroidism. Not fun and very dangerous.

Support Med. profile image

Support Med. Level 3 Commenter 16 months ago

There is so much involved in our good health; genetic make-up, our choices (a big one) and as Seakay said, knowledge of the thyroid which affects every system of the body, including the brain. Our choices, as you stated, have a lot to do with it (even with the involvement of genetics). Voted and rated.

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